5-HT2B antagonist-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

5-HT2B antagonist-1 是一种具有口服活性的 5-HT2B 受体拮抗剂，其 IC50 值为 33.4 nM。可用于以 5-HT2B 受体信号传导为特征的疾病研究，如肝细胞癌、心血管疾病或胃肠道疾病。

5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease.

5-HT2B antagonist-1 (compound 5g) has some sodium channel binding activity with IC50 values in the range of 12.6 to 57.5 μM.5-HT2B antagonist-1 (coumpound 1-e) inhibits 5-HT2B receptor activity by less than 50% at 1 μM in CHO-K1 cell lines.

5-HT2B antagonist-1 (compound 15) (oral gavage, 30 mg/kg) can reduce visceral hypersensitivity significantly in irritable bowel syndrome (IBS) rats.

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Others

Other Targets

Others

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393129-91-4

296.17

C11H14BrN5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 33.33 mg/mL (112.54 mM ) H2O 中的溶解度 : 12.5 mg/mL (42.21 mM; 超声助溶 (<60°C)

CC1(C)NC(Nc2ccc(Br)cc2)=NC(N)=N1

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(-20℃)

With Ice Pack

≥ 2 years